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You are here: Deprex™ > Depression

Depression

The cause of most depressions

Serotonin and norepinephrine producing centers and interactive pathways become disrupted and imbalanced regarding respective receptor sensitivities and inhibitory mechanisms, and the hypothalamus becomes dysfunctional.

Region of the brain responsible for the production of serotonin and norepinephrine. An imbalance of these neurotransmitters is known to be the cause of depression.

Pictured above: is a cross section of the brain and the pathways responsible for serotonin and norepinephrine production and distribution, and the hypothalamus. Biochemical disruption in these areas have been shown to result in various forms of depression.

What is depression and why do we experience it?

There are three major neurotransmitters in the brain:

  • serotonin
  • dopamine
  • norepinephrine

which must be in the correct balance and constructive tension to affect and allow a positive, stable self-image and optimistic mood. However, when these neurotransmitters are in an unbalanced state with one another, mood changes are inevitable. In general, when serotonin levels drop, depression can quickly settle in, and when serotonin levels can be made to rise, a happy contented mood generally results.

Researchers have found that hypothalamic disturbances are also found in depression, interfering with neuroendocrine activity. Hypothalamic disruptions can cause excessive amounts of cortisol to be released from the adrenal cortex at inappropriate times which can cause and exacerbate depression. And, interestingly, about one-half of all depressed patients secrete excessive amounts of cortisol, primarily during the afternoon and evening, as opposed to that of non-depressed people whose cortisol activity peaks about 8:00 AM.


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