PermaSlim
For best results, PermaSlim may be used in conjunction with 2-Day Slim Down, but can also be used by itself as a mild appetite suppressant.
PermaSlim
Product description
PermaSlim is a dietary weight loss formula based on cutting edge research. Citrus Aurantium, a mild fat burning formula, Vitamin B6 and B12, along with Green Tea extract are combined in a proprietary synergistic blend to enhance your body's ability to achieve and maintain optimal health.
Citrus Aurantium is commonly referred to as Bitter Orange. Zhi shi is the immature dried fruit of Citrus Aurantium. Zhi has been used in traditional Chinese medicine to treat chest congestion and stimulate gastrointestinal functions.
Key compounds in Citrus Aurantium:
Extracts from Citrus Aurantium contain a rare combination of five adrenergic amines:
- Synephrine
- N-methyltyramine
- Hordenine
- Octopamine
- Tyramine
Citrus Aurantium mechanism of action:
The amines in Citrus Aurantium stimulate ß-3 cell receptors with less of an effect on other α and ß receptors. Stimulation of these ß-3 receptors elicits the breakdown of fat. Simultaneously, this stimulation causes an increase in the metabolic rate – thermogenesis – which burns calories. Citrus aurantium may also act as an appetite suppressant.
PermaSlim promotes:
- thermogenesis
- appetite suppression
with no side effects, or stimulants like caffeine or Ephedrine.
Product description
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A bottle of PermaSlim |
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Product description
- 60 capsules per bottle
- 30 day supply
Product description
PermaSlim is known to:
- promote a safe weight loss
- burn fat
- suppress appetite
Product description
Take 2 capsules daily or as directed by a health care professional.
For maximum effectiveness PermaSlim should be used in conjunction with 2-Day Slim Down.
PermaSlim may also be used by itself.
Product description
PermaSlim supplement facts:
Serving size: 2 capsules
Servings per container: 30
| Amount per serving | %DV* | |
| Vitamin B12 | 100 µg | 1,650% |
| Vitamin B6 | 16 mg | 800% |
| Proprietary blend: | 600 mg | |
| Citrus Aurantium | + | |
| Green Tea extract | + | |
| + Percent Daily Values (%DV) are
based on a 2,000 calorie diet. + Daily Values (DV) are based on a 2,000 calorie diet. |
||
Other ingredients:
- Cellulose
- Magnesium stearate
- Silicon dioxide
Product description
- Pregnant or nursing women must not use PermaSlim.
- Increased body temperature may occur as the dose is increased. Drink plenty of cold water. The use of Citrus Aurantium may increase blood pressure.
- Citrus Aurantium extract may help control appetite, but caution is advised. Use the least amount possible and take breaks from use.
- Do not take Citrus Aurantium daily for many weeks without a break.
- Consult a physician before beginning any weight loss program.
- If you have a poor or specific health conditions, if you are taking medicines or have a chronic health condition, consult your physician first before using PermaSlim.
Product description
- Shelf life is 1 year for an opened or unopened product
Product description
PermaSlim contains Vitamins B12 and B6, two of the most potent fat-burners, to naturally help your body enter and stay in thermogenesis - a natural fat burning state that seriously boosts your metabolism. The result is that you burn calories - in the form of fat - all day.
PermaSlim contains Vitamins C and E, widely accepted as two of the most powerful antioxidants available - to help your body cleanse itself of the toxins that are released as you burn unwanted fat.
PermaSlim also contains Green Tea extract for increased energy. Green Tea extract is a potent antioxidant that has been found to improve digestion and is believed to help lower cholesterol. When combined with Citrus Aurantium, a mild fat burner and potent appetite suppressant - as it is in PermaSlim - it helps to burn calories at an accelerated rate.
This formula does not contain the controversial alkaloid Ephedrine, known to be contained in the herb Ma Huang or Ephedra. Instead, PermaSlim is designed to naturally increase your energy levels with healthful vitamins and herbs throughout the day.
Adrenergic amines
Until recently, Ma Huang (Ephedra Sinica) was considered to be one of the most effective natural weight loss agents available. At the cellular level, Ephedrine, the main active ingredient in Ma Huang, is a powerful adrenergic agent that activates two types of cell receptors - called a α and ß cells - to stimulate lipolysis (the breaking down of fat into free fatty acids and glycerol) and thermogenesis (the production of body heat in the muscles and fat). α- and ß-receptors are found on the surface of every cell in the body and normally respond to the stimulatory effects of the two primary adrenergic amines (nitrogen-containing compounds) produced by the body - adrenaline and noradrenaline. The specific cellular response to adrenergic amines is determined by the location, number and type of different α and ß-receptors: α-1 and α-2, and ß-1, ß-2, and ß-3. In general, receptor types and their responses are described as follows:
- α-1 receptors: causes constriction of arteries and potential increase in blood pressure.
- α-2 receptors: affects blood pressure by constricting peripheral blood vessels, inhibits lipolysis.
- ß-1 receptors: affects cardiac function, causes bronchodilation and dilation of blood vessels in heart and skeletal muscle.
- ß-2 receptors: affects cardiac function, causes bronchodilation and dilation of blood vessels in heart and skeletal muscle.
- ß-3 receptors: increases rate of fat release from body stores (lipolysis) and increases resting metabolic rate (thermogenesis).
The α (and ß) of Ephedra
While Ephedra has been shown to be an effective agent for triggering thermogenesis, one of the continuing problems has been the potential for cardiovascular and central nervous system over-stimulation in certain individuals. The reason for these unwanted side effects becomes clear when one looks at the type of cell receptors targeted by Ephedra. Ephedra makes contact with - and elicits responses from - both α- and ß-receptors. The primary benefits seen with Ephedra are due to stimulation of ß-3 receptors, which causes an increase in lipolysis and thermogenesis. Unfortunately, Ephedra also stimulates the ß-1 and ß-2 receptors, potentially causing over-stimulation of the cardiovascular and central nervous systems - the classical 'fight or flight' response. Ephedra also stimulates both of the α-1 and α-2 receptors, which, as seen above, causes arterial constriction and increased blood pressure. Additionally, by stimulating α-2 receptors Ephedra has the undesirable effect of blocking lipolysis - exactly the opposite effect one desires when trying to control weight.
Bitter Orange extracts more effective than Ephedra
Recently researchers from McGill University in Montreal isolated five adrenergic amines from bitter orange (Citrus aurantium): synephrine, N-methyl-tyramine, hordenine, octopamine, and tyramine. While these alkaloids are similar to those found in Ephedra, they work on a different set of receptors to stimulate lipolysis and thermogenesis.
Laboratory tests have found that Citrus aurantium alkaloids show properties similar to Ephedrine, by triggering ß-receptors. More recently, studies have shown that both octopamine and synephrine appear particularly effective in stimulating lipolysis, a postulated ß-receptor effect. Other researchers had previously revealed that synephrine was about 3.5 times as effective in stimulating lipolysis as octopamine, leading researchers to state that 'the alkaloid mixture in bitter orange extract is superior to the mixture of Ephedrine alkaloids in ma huang (Ephedra sinica) in terms of effects on ß-receptors in general.
Fewer side effects than Ephedra
Researchers were most impressed by the fact that these amines increase lipolysis and thermogenesis without causing the elevated blood pressure, muscle disturbances, insomnia, dry mouth, heart palpitations, and nervousness sometimes caused by Ephedra.
Thus though citrus alkaloids appear to be at least as thermogenic as the Ephedrine alkaloids, they are clearly gentler than the latter and do not cause the minor side effects associated with use of Ma huang (nervousness, agitation, palpitations, increases in blood pressure). The better tolerance of the citrus alkaloids is thought to be because they do not pass so readily into the brain, and may target fat cells more specifically.
Citrus amines selective for ß-3 receptors
The amines contained in Ephedra - adrenaline and noradrenaline - are highly lipophilic, meaning that they are readily attracted to fats and easily cross the fatty membranes that comprise the blood-brain barrier. Once past this protective barrier, adrenaline and noradrenaline target the α-1 and α-2 and ß-1, ß-2, and ß-3 receptors to cause amphetamine-like effects on the cardiovascular and central nervous systems believed to occur with Ma Huang.
By contrast, research shows that the amines found in Citrus Aurantium extract make minimal contact with the α and ß-1 and ß-2 receptors, but exert their adrenergic effects by acting exclusively on ß-3 receptors to stimulate lipolysis and increase resting metabolic rate.
How does PermaSlim work?
Citrus aurantium extract (PermaSlim) is an exceptional alternative to Ma Huang. Both safe and natural, it functions in four specific ways:
- Increasing lipolysis (breaking down fat stores to be used as fuel
- Stimulating weight loss by enhancing thermogenesis (burning of fat)
- Increasing fuels available for physical performance
- Helping to spare and maintain lean muscle mass
PermaSlim activates your body's internal "fat burning furnace" by enabling it to burn fat while reserving critical lean muscle tissue. This statement is important because pound for pound, lean muscle tissue burns more calories than fat. By helping you to shed the fat and keep the muscle, PermaSlim actually gives your metabolism a natural calorie burning boost.
In addition, PermaSlim has been formulated to help restore the biochemical and mineral balance in your tissues and cells as well as assimilate vital trace elements, enzymes and minerals into the blood stream. So, not only will you lose fat, you'll gain stronger tissues and cells. The capsules also contain 100% of the Recommended Daily Allowance or RDA of all the vitamins and minerals your body needs to sustain good health, while you are losing weight.
PermaSlim contains an all-natural appetite suppressant to help you keep your urge to overeat under control. We all know the temptation that our favorite foods represent. Most people say that the hardest part of any weight loss program is avoiding the foods that made them gain weight in the first place. But with PermaSlim, you don't have to avoid your favorite foods.
That's because PermaSlim is designed to work with the foods you normally eat. No more special dietary requirements. No more missing out on the foods you love. The all-natural appetite suppressant will help you control how much you eat. Once you get used to eating less, you will probably find that you feel better on less food. Many people find that they naturally shift to making healthier food choices as they begin to feel better. What could be easier?
The only change that we recommend you make to your regular routine is to drink a minimum of 8 glasses of water each and every day. Because water is vital to the fat-burning process, it is the most important element of any healthy weight loss program. For that reason, you will want to be sure you're getting enough water to keep your body at peak fat-burning performance.
What about exercise? Many people find that they have more energy and lose fat faster if they get approximately 30 minutes of exercise 4 to 6 days a week. This can be walking, cycling, swimming, skating ... or any activity you enjoy. Just start out slowly and gradually increase your activity over a period of several weeks, to give your body time to adjust. Since you'll be losing fat and keeping lean muscle, exercise will give you the added benefit of helping to shape and firm your body as you shed excess pounds.
Key ingredients in PermaSlim:
- Vitamin B6 (antioxidant)
- Vitamin B12 (fat burner)
- Citrus Aurantium (mild fat burner, appetite suppression)
- Green Tea extract (antioxidant)
Caution:
Always consult a physician before beginning any weight loss program.
Do not use if pregnant, nursing or diabetic. Anyone with any specific condition should consult their doctor if they have any questions.
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